Our lab studies the molecular, cellular, and subcellular mechanisms involved in synaptic transmission and reward-related behaviors using cutting-edge techniques to delineate cortico-basal ganglia circuit dysfunctions that underlie neurodegenerative diseases, as well as substance use disorders. Neuromodulators via G-protein coupled receptor (GPCR) activation play important roles in the modification of synaptic activity. These synaptic changes are…