Sanford Chamber of Commerce – Connect, Promote, and Grow Businesses Across Central Florida for Over 100 Years. The Sanford Chamber of Commerce exists to Connect, Promote, and Grow businesses of all sizes throughout Central Florida. With a rich legacy spanning over a century, we are committed to fostering economic growth, providing valuable resources, and creating meaningful connections that help businesses thrive and succeed. Whether you're a startup, small business, or large corporation,