Learn about Avmapki™ Fakzynja™ Co‑Pack (avutometinib capsules; defactinib tablets), a prescription medication for adult patients who have low-grade serous ovarian cancer (LGSOC) that has come back (recurrent), and LGSOC with an abnormal KRAS gene, and previously been treated with medicine for their cancer. See Prescribing Information for serious side effects including eye problems, severe skin reactions, liver problems, muscle problems (rhabdomyolysis), and harm to unborn babies.